Greg Ward Jr. lead the Cougars with 161 yards passing, two touchdown passes and 119 yards rushing. Houston was able to out-gain the Bearcats on the ground, 266 to 66 yards.
On the defensive side, Brandon Wilson and Steven Taylor grabbed one interception a piece as the Coogs stopped Cincinnati late to secure the victory.
Tied at 14, the Coogs struck first after the halftime break with a touchdown pass from Ward Jr. to Tyler McCloskey followed by a 51-yard interception return by Wilson that put Houston up 28-14.
"We just knew coming into this game we had to execute on every unit," linebacker Elandon Roberts said.
A big showdown is set for next week as the undefeated Memphis Tigers make their way to Houston to face the Cougars.