Spokesperson Jim McGrath issued a statement that the former first lady is in comfort care.
"Following a recent series of hospitalizations, and after consulting her family and doctors, Mrs. Bush, now age 92, has decided not to seek additional medical treatment and will instead focus on comfort care," McGrath said. "It will not surprise those who know her that Barbara Bush has been a rock in the face of her failing health, worrying not for herself -- thanks to her abiding faith -- but for others. She is surrounded by a family she adores, and appreciates the many kind messages and especially the prayers she is receiving."
Sources confirmed to ABC News that Bush left Methodist Hospital and is now at home with her family.
Barbara, wife of former President George H.W. Bush, served as first lady during his presidency from 1989 to 1993.
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Mr. and Mrs. Bush have been a fixture in the Houston community during their retirement years.
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Barbara is currently the nation's oldest living First Lady.