It happened near Kings Park Way around 11 a.m., according to the Atascocita Fire Department.
Firefighters were on scene putting out a small vehicle fire that erupted after the impact.
The fire department tweeted a photo from the scene showing crews cleaning the area.
There was no word on the condition of those involved in the crash.
ALERT: FM 1960 E. near Kings Park Way in Humble closed in both directions due to major accident with roll-over and vehicle fire. Incident now in investigative and clean-up phase. pic.twitter.com/2l0w5nqT0n— Atascocita Fire (@atascocitafire) December 20, 2020