Uber confirmed the driver of the SUV was working for them and was carrying a passenger.
Witnesses on a bus said they saw the 2007 Nissan X-Terra speed past them, then clip the side of a Honda Accord, which pushed the car off the road.
The car ended up hitting a tree and split in half.
The 35-year-old driver of the Accord was trapped inside. He was freed and taken to Harborview Medical Center with serious injuries.
Witnesses said the SUV kept heading eastbound, and it appears the driver tried to brake then lost control. They said the SUV may have blown a tire.
Surveillance video shows the SUV went airborne over a curb, through a parking lot, then plowed into a Shell Gas Station.
The SUV missed two gas pumps, but hit a third and burst into flames. Firefighters quickly put the fire out.
A 40-year-old woman who was a passenger in the SUV was taken to a hospital with minor injuries.
The SUV driver was evaluated at the scene for signs of impairment. He was taken to a hospital where a sample of his blood was taken after a warrant was obtained.
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