The accident happened around 11:00 a.m. on the northbound ramp from Route 90 to Route 130.
Chopper 6 was over the scene where two fires could be seen - one approximately 100 yards behind the burning remains of the truck.
It is unclear what led to the crash.
Authorities say the driver - who apparently was alone in the truck - was able to get out of the vehicle. But it wasn't immediately clear if the driver suffered any injuries.
Firefighters are dousing the blaze with foam from across the highway.
Nearby homes are being evacuated as a precaution, and traffic is being diverted from the area.
Stay with Action News and 6abc.com as more information becomes available.
Information from The Associated Press was used in the writing of this post.