The victim died after he was struck on the highway near 610 around 11pm Wednesday.
PHOTOS: Man killed while crossing Gulf Fwy
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HPD said at least one person ran away from the crash scene, leaving the pickup truck behind. They believe there were other people who took off with the driver.
Detectives told Eyewitness News they have been to the house where the truck is registered, and the woman who lives there said the truck is owned by her husband.
RAW VIDEO: HPD says suspects ran from deadly hit and run scene
The woman allegedly claimed her husband doesn't live there, but a neighbor who we are not identifying denied that woman's claims. She said the man does live at the home.
A witness told police she saw the white Ford pickup truck as it swerved around her vehicle, right before plowing into the pedestrian.
The wrecked truck stopped right before 610, in the median.
The eyewitness saw everyone in the truck bail out of the vehicle, running away together into the night.
RELATED: String of pedestrian deaths highlight Houston road dangers
Where they went is anybody's guess at this point, but police believe the truck may lead them to the suspects.
SEE ALSO: Man struck and killed on Gulf Fwy as son watches
Sadly, this kind of tragedy is not unknown to the Gulf Freeway.
Last July a man was struck and killed right in front of his son while checking out damage to his red Avenger.
The man had hit a guardrail near Tellepsen, and got out to check when he was hit by a pickup truck.
RELATED: Pedestrian hit, killed on Gulf Freeway at Broadway
Then, in October, a man was killed while trying to cross the Gulf Freeway at Broadway.
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