The horrifying accident happened at about 1:15am on the North Freeway. Houston police say the tractor trailer struck a metal guardrail and a concrete pillar before rolling over and catching fire.
The driver appeared to have been ejected and died at the scene.
EXCLUSIVE VIDEO: Aftermath of fiery big rig crash on North Fwy
VIDEO: Houston police give update on deadly big rig wreck on North Freeway
His two sons, 5 and 2, were passengers in the truck. The older boy pulled his brother from the truck. Both children were transported to Memorial Hermann Hospital. The older boy had minor injuries while his brother suffered severe burns.
Their mother was said to be unaware of what happened because she was traveling ahead of the big rig. Deputies worked to reunite the woman with her children.
Houston police say the family was on their way to Galveston, where they were moving to a new home.
PHOTOS: Deadly big rig crash on North Freeway at Aldine Bender
Exclusive video into Eyewitness News shows the dramatic aftermath of the wreck.
Dhaval Shah was one of the first eyewitnesses on the scene. His father owns a hotel not too far from where the accident happened, and says he heard a loud boom.
Father in 18 wheeler dies in fiery crash. 2 young sons injured. 45 southbound near Beltway 8 pic.twitter.com/oXcMnu6eJf— Jeff Ehling (@JeffEhlingABC13) October 14, 2016
When he came outside, he saw a little kid running around and a big fire covering the truck.
The boy told Shah his father had crashed into the guardrail, and the truck flipped over.
We're following this story on Eyewitness News. Watch for updates on air, online and on our mobile news app.
Keep checking back on this page to get real-time updates as this story unfolds. To get alerts for breaking news, download the abc13 news app for iPhone or Android. You can also get breaking news alerts sent to you by email.