A family spokesperson said Wetzel, an environmental specialist, was in a small meeting when suspected shooters Syed Rizwan Farook, 28, and Tashfeen Malik, 27, burst inside the social service center and opened fire.
His widow, Renee Wetzel, learned of his death late Wednesday night.
"They are very overwhelmed," family spokesperson Celia Behar said. "There are six kids that have lost their father and Renee is a stay-at-home mom, so they've also lost all of their financial support, and the kids are just finding out today."
Twenty-one others were wounded in the massacre. Authorities are still working to determine the couple's motive.
Wetzel leaves behind a widow and six children ranging from an infant to a teenager.
Friends of the Wetzel family have set up a YouCaring account to help them in this time of need. You can donate here: www.youcaring.com/renee-wetzel.
Below are some of the other victims killed Wednesday.
- Nicholas Thalasinos, a fellow employee of the department of health for twelve or thirteen years. He was married.
Damian Meinsel, a fellow employee who also worked for the Riverside County Transportation and Land Management. His wife was a local principal
Daniel Kaufman, 42-year-old, employee of coffee shop at Inland Regional Center