The crash was reported at about 1:20 p.m. at Vanowen Street and Hayvenhurst Avenue in the Lake Balboa district.
PHOTOS: Small plane crashes near Van Nuys Airport
One person on board was declared dead at the scene. Their name has not been released. No other injuries were reported.
The single-engine Lancair did not hit a vehicle or structure when it crashed, and it also did not catch fire, officials said.
It is not yet known what caused the plane to crash.
The intersection has been shut down due to the investigation. Drivers were advised to avoid the area.