The arrests happened in a motel off the North Freeway near FM 1960.
Investigators said the girl was a runaway from Chicago and being forced into prostitution.
Deputy constables said 20-year-old Teresa Henry and 24-year-old Centurrie Deshunn Garrett used social media to convince the girl to come to Houston.
The pair allegedly advertised the girl as a 19-year-old on a sexually-oriented website. Undercover officers saw her photo and set up a meeting at the North Villa Inn where she was rescued.
"Basically, what we had is a 14-year-old female that was lured down to Houston by these other two females and basically put into prostitution here in Houston," Harris County Pct. 4 Constable Mark Herman said.
Henry is charged with human trafficking of a minor and compelling prostitution of a minor.
Authorities said when they met with the girl, Henry was also in the room orchestrating the deal. Garrett was found in an adjoining room with her 6-week-child, who was later taken into CPS custody.
"The main thing is we rescued the 14-year-old girl and we got her off the streets in a safe environment. We got these two suspects off the streets and in jail, [so now] the streets of Harris County are much safer," Herman said.
The girl is in protective custody and will be reunited with family in Chicago.
It is possible there could be additional underage victims and further charges.
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