The right lanes are now reopening after being shut down for more than 30 minutes.
Police say at 1am, they received a call about a man who was shot. He was found lying in the U-turn lane at Almeda Genoa.
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The man died at Ben Taub Hospital a short time later. Police say there were no witnesses.
Investigators are at the scene taking photographs while traffic is shut down.
We're following this story on Eyewitness News. Watch for updates on air, online and on our mobile news app.