HPD says the officers were entering I-610 near MLK Boulevard around 3 a.m. when they lost control.
Both officers were taken to the hospital, but are expected to be okay.
Investigators say the officers crashed during a pursuit where at least six people tried to break in to a Fiesta store on I-610 near Mykawa.
Westbound lanes of IH-610 South Loop before Cullen are shut down for a major accident. Expect delays and find alternate routes #hounews CC13— Houston Police (@houstonpolice) September 1, 2020
An HPD officer reportedly spotted them in the act and the chase began.
The suspects ended up crashing off US-59 and Collingsworth, according to police.
Investigators say two suspects have been caught and four are still on the run.