The event attracts hundreds of joggers every year who are ready to strip down to their underwear in the name of charity.
PHOTOS: Check out the 2014 Hot Undies Run
The party is set to start at 11:00am at the "Gorgeous Gael Irish Pub" in Rice Village. Eyewitness News caught up with some participants early this morning who say they're ready to let loose.
The pub run benefits the "Muscular Dystrophy Association" and "Undies for Everyone."
Registration is still open to the public. You can find more information on how to join in on the fun at https://thedriven.net/hot-undies-run/.