In a statement, the country's government said José Rómulo Sosa Ortiz, "became one of the most beloved voices in Mexico. RIP."
He passed away in Miami, Fl. The official cause of death was not immediately disclosed.
In March 2017, the iconic singer announced he had been diagnosed with pancreatic cancer and underwent chemotherapy, according to CNN.
"Thank you for your support and for your prayers," José José said to his fans on Twitter in June. "I am very well, thanks be to God. I'm continuing with my therapies to move forward so that we will see each other soon, thanks for everything, a hug and a thousand blessings to all."
José José was known for his unique interpretations of romantic ballads. He was honored with a star on the Hollywood Walk of Fame in 2014. The Hollywood Chamber of Commerce said a wreath will be placed at the star Monday morning.
Desde la Secretaría de Cultura lamentamos el sensible fallecimiento del cantante José Rómulo Sosa, mejor conocido como José José o el príncipe de la canción. Desde los inicios de su carrera, el intérprete de El triste se convirtió en una de las voces más queridas de México. QEPD pic.twitter.com/YRVmEAtcoC— Secretaría de Cultura (@cultura_mx) September 28, 2019
José José is survived by his wife and six children.