"It's very bittersweet to leave this fantastic community behind and all these partners," Dr. Shah told ABC13 during Thursday night's COVID-19 Vaccine Town Hall.
He's taking a new job as the next health secretary in Washington state after leading Harris County's health department since 2013.
RELATED: Harris Co. Public Health Authority Dr. Shah warns of pandemic fatigue before leaving post
County commissioners have launched an expedited nationwide search to replace Shah. For the time being, Deputy Director Gwen Sims will fill in.
During Thursday's town hall, Dr. Shah had a lot to say about the vaccine.
"When your time is called, get the vaccine because it's safe, it's effective, and certainly we want to do everything we can so we have that light at the end of the tunnel," Dr. Shah advised.
"I believe I'm behind a great team. So really, everybody is in good hands. I just want to make sure everybody remembers that as well," he said.
Dr. Shah is taking no time to get started in Washington state. His first day is Monday.
Follow TJ Parker on Facebook, Twitter and Instagram.