Capt. Rita Reith says a motorist along Interstate 70 reported the fire about 9:10 a.m. Saturday but subsequent 911 calls helped fire officials determine the home's location.
Reith says firefighters pulled the parents and their four children, all in critical condition, from a small bungalow-style home and quickly extinguished the fire.
She says the parents, a man in his early 40s and a woman in her early 30s, were pronounced dead at a hospital.
Two of the children were pronounced dead at Riley Hospital for Children, where their two siblings remain hospitalized in very critical condition.
Take ABC13 with you!
Download our free apps for iPhone, iPad, and Android devices