Capt. Rita Reith says a motorist along Interstate 70 reported the fire about 9:10 a.m. Saturday but subsequent 911 calls helped fire officials determine the home's location.
Reith says firefighters pulled the parents and their four children, all in critical condition, from a small bungalow-style home and quickly extinguished the fire.
She says the parents, a man in his early 40s and a woman in her early 30s, were pronounced dead at a hospital.
Two of the children were pronounced dead at Riley Hospital for Children, where their two siblings remain hospitalized in very critical condition.
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