Maurice Jones-Drew ran for a season-high 84 yards and a touchdown and the Jacksonville Jaguars extended the Texans' losing streak to a franchise-record nine games with a 13-6 victory.
The two-time AFC South champions haven't won since Sept. 15.
Jones-Drew's touchdown on Jacksonville's first drive put the Jaguars (2-9) on top, and they never trailed against an inept and ineffective Texans offense.
Josh Scobee kicked field goals of 30 and 53 yards to help the Jaguars win for the second time in three games.
Case Keenum had the worst performance in his five starts, throwing for just 169 yards with an interception.
Houston (2-9) was driving late when rookie Ryan Davis grabbed a one-handed interception off a deflection by Keshawn Martin to seal the win.
The Jaguars pushed their lead to 13-6 with Scobee's 53-yard field goal with about seven minutes remaining.
Houston got lucky on its next drive when Keenum threw a ball right into the hands of Jacksonville rookie Johnathan Cyprien, but he couldn't hold on to it. It didn't matter much though as the Texans ended up punting a few plays later anyway.
Jacksonville entered the game averaging an NFL-worst 61.7 yards rushing a game, but finished with 118.
Jones-Drew found some room in an otherwise tough season and added 60 yards on six receptions.
Chad Henne was 23 of 32 for 239 yards and Cecil Shorts led the team with eight catches for 71 yards.
Houston coach Gary Kubiak coached from the booth for the second straight week on the advice of his doctors after returning to work last week after recovering from a mini-stroke.
Henne was sacked and fumbled on third down late in the third quarter. The Jaguars recovered and attempted a 49-yard field goal, but J.J. Watt swatted it down and the Texans returned it 25 yards. It was the second time this season that Watt has blocked a field goal.
Houston didn't take advantage of the opportunity, and Jacksonville got the ball at its 40 after Dennis Johnson was stuffed for no gain on fourth-and-1 early in the fourth quarter.
Rookie Denard Robinson came in for one play on Jacksonville's next drive, and launched a long and accurate pass on third-and-5 downfield to Shorts. But Johnathan Joseph was there to break it up and the Jaguars had to punt again.
Jones-Drew gave the Jaguars an early lead when he scored on fourth-and-1 from the 1 on the first drive. Jones-Drew had a 41-yard catch and run and Ace Sanders grabbed a 51-yard pass to set up the score.
Jones-Drew had a 44-yard run in the second quarter on a drive that ended with a 30-yard field goal by Scobee to make it 10-0.
Houston hadn't made a first down on four straight possessions and had just 20 total yards before a 29-yard run by Johnson 4½ minutes before halftime. But the offense soon stalled again after Keenum was sacked and the Texans settled for a 49-yard field goal to cut the lead to 10-3 at halftime.
Keenum was terrible in the first half, going 5 for 12 with 32 yards. His tough day started early when he was sacked by Andre Branch for a loss of 19 yards on third down on Houston's first series.
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