The accident, which happened around 11am, blocked FM 1960 at Artesian Way for six hours.
Authorities say a speeding pickup truck with three teenagers inside was heading westbound on 1960 when it lost control.
"According to witnesses at the scene, (the driver) veered into the oncoming lanes and struck three other vehicles, hitting one of the vehicles head-on and killing that driver," said Deputy Leo Anders with the Harris County Sheriff's Office.
In all, three other vehicles were struck: the one in which the victim, an elderly male, died; a Jeep, which rolled into a ditch, and sent the driver to the hospital in critical condition; and a minivan carrying a mother and child.
The teenage driver of the pickup and one of his passengers were transported by Life Flight to a hospital, and another two were transported via ambulance.
No names have not yet been released.
The Harris County District Attorney's Office is at the scene investigating.
We're told at this point, there's no obvious sign that alcohol may have been a factor in the collision.