The accident happened around 4:34pm on Highway 6 South at Piping Rock, which is just north of Westheimer.
SkyEye HD was over the scene, and it appeared at least seven cars were involved in the wreck. One vehicle was overturned, while another two appeared to have collided head on.
One person was killed, and multiple injuries have been reported.
Traffic on that stretch of the highway has come to a standstill, as crews shut down both directions of the highway to tend to the scene.
Stay with Eyewitness News and abc13.com for the latest details.
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