It happened just before 1:30pm Sunday in the 200 block of Interstate 45 North at Cottage.
According to a METRO spokesperson, a vehicle was stalled in a lane due to a flat tire. A second vehicle rear-ended it, causing a chain-reaction crash involving a total of four vehicles, officials said.
A pedestrian was struck in the crash and was reportedly trapped under a METRO bus. That man died at the scene, officials said.
Five others were injured in the string of accidents. Authorities said four were transported with non-life-threatenig inuries and the fifth was treated at the scene and released.
Investigators shut down the roadway for a couple hours while they investigated and cleared the wreckage. METRO police are investigating the incident.