Landry Jones threw for 321 yards and two touchdowns, and fullback Trey Millard had a career-best 119 yards receiving as the Sooners (4-1, 2-1 Big 12) added another rout to Bob Stoops' impressive rivalry resume.
Stoops is now responsible for three of Oklahoma's five most lopsided wins over Texas -- and that doesn't include last year's 55-17 clobbering.
The Longhorns (3-2, 1-2) couldn't get a stop and never got their offense going, then lost quarterback David Ash to an apparent left wrist injury in the fourth quarter.