"Life with La Toya" is described as a "candid look" inside Jackson's life as she juggles family, friends and business. It will air next year on Winfrey's TV network, OWN.
La Toya is one of Katherine and Joe Jackson's nine children and was Michael's sister.
She isn't the first Jackson to get a reality show. "The Jacksons: A Family Dynasty" aired for six episodes on A&E. It followed Jermaine, Jackie, Marlon and Tito Jackson.
La Toya also competed last year on "Celebrity Apprentice."