The head-on collision happened around 1:30am Sunday on the North Freeway near Woodlands Parkway.
Officials tell us a white car driven by 42-year-old Edward Blackwell was southbound on the I-45 feeder when it was spotted swerving.
"Witnesses state that vehicle was traveling southbound on the southbound feeder service road, made a U-turn and entered the entrance ramp just north of Woodlands Parkway and proceeded northbound in the southbound I-45 mainlanes," DPS trooper Erik Burse said.
Seconds later, Blackwell crashed head-on into a Pontiac G6.
Investigators tell us he was not only traveling in the opposite direction of traffic, he was also speeding at the time of the crash.
"This is a very sad situation," said . "It's not a road problem. It doesn't appear any signs or road markings would have someone turn around and do that."
Blackwell's 47-year-old passenger died on impact. He has not been identified.
The Pontiac had two people inside -- a 25-year-old driver and her 27-year-old male passenger. Both were pronounced dead at the scene of the crash. Their names also have not been released.
Blackwell survived the crash and was taken by Life Flight to Memorial Hermann Hospital in critical condition.
Autopsies will be performed Monday in Conroe on all three victims, along with toxicology tests to see if alcohol was involved.
Troopers suspect Blackwell and his passenger were both intoxicated, but the Montgomery County District Attorney's Office said it is too premature in the investigation to press charges against Blackwell because of his condition.
Investigators are working with the Texas Alcoholic Beverage Commission to track down where Blackwell and his passenger had been earlier in the night.
This is the second wrong way accident to happen in Montgomery County in the past two days. Troopers added this is a No Refusal weekend. Anyone caught drinking and driving will go to jail.
Please stay with Eyewitness News and abc13.com as we continue following this story.