The child will be born later this summer via a gestational surrogate, meaning the baby will be genetically theirs but carried by another woman.
E! News first reported the news that they are expecting.
Last fall, 37-year-old Giuliana announced she had breast cancer and later underwent a double mastectomy. She did not need chemotherapy.
Giuliana is the host of E! News. Bill is a 40-year-old entrepreneur and motivational speaker who won the first season of Donald Trump's "The Apprentice."
Together, they co-star in a reality show on the Style Network called "Giuliana & Bill." Much of the show has been devoted to their fertility issues.