The rule takes effect Wednesday.
For years, hundreds of Texas ranchers have made big money on exotic antelopes. Hunters pay up to $10,000 to bag just one dama gazelle.
The new rule says hunting the dama gazelle, the scimitar-horned oryx and the addax isn't allowed unless ranchers obtain a permit.
But the Texas-based Exotic Wildlife Association says just 10 percent of ranchers have sought the permits.
Animal-rights groups are happy with the change.
The animals were listed on the Endangered Species Act but were exempt from the no-hunting rule by the U.S. Fish and Wildlife Service.
That rule will now be enforced.