State troopers say the motor home was towing a minivan this afternoon on U.S. 59 near Fostoria.
The trailer crashed in the woods. Witnesses started breaking windows to try rescue the driver, but they had to run for cover when propane tanks started exploding and the trailer caught fire.
The driver died in the blaze.
The victim's identity has not been released.
Northbound lanes of the highway were blocked for more than five hours while crews investigated the accident and cleaned debris from the road.
