According to the Houston Fire Department, the tractor-trailer hit the guardrail on the westbound side of I-10 just before Taylor.
Officials said 150 gallons of diesel fuel leaked onto the road, along with 50 to 100 gallons of oil. Hazmat crews cleaned up the mess.
No injuries were reported and the freeway reopened Sunday afternoon.
For real-time traffic conditions and travel times, go to the ABC13 Traffic page.