Pennsylvania Game Commission spokesman Jerry Feaser says the attack happened Monday morning in Oliver Township. He says the couple's dog was outside and ran into the home, followed by the bear.
Feaser says the man inside the home was scratched and bitten and a woman was attacked as she tried to chase the animal away.
Emergency dispatchers say both were taken to Harrisburg Hospital with unspecified injuries.
State police in Newport directed inquiries to the Pennsylvania Game Commission.
Oliver Township is near Newport in largely rural Perry County, about 20 miles northwest of Harrisburg.