The Tomball Parkway will be shut down northbound at Grant/Schroeder from 9pm Friday night through 5am Monday. Drivers will have to detour to the Grant/Schroeder exit and re-enter at the next entrance.
Also, Crosstimers eastbound and westbound at I-45 will be shut down from 9pm Friday night through 5am Monday. Eastbound traffic should detour to the Northern Railroad turnaround. Westbound traffic is detoured to the Airline U-turn.
Finally, North Main Street northbound and southbound from Naylor Street to Franklin will be completely shut down through October 1, 2012. Signs should get you around the closure.
For a full list of closures and detours, check the Transtar website.