The network says Lopez's Thursday night show will be the final one. "Lopez Tonight" is in its second season.
The comic gave up his 11 p.m. time slot to make room for Conan O'Brien, who joined TBS after leaving NBC's "Tonight" show. The plan for TBS was to have a one-two punch of late-night shows that would particularly appeal to young viewers.
TBS says in a statement it was a "difficult decision."