He will again face off against Argentine polo player Nacho Figueras, who is also a model for Ralph Lauren.
The event will benefit American Friends of Sentebale, the U.S. arm of the global charity co-founded by Harry. The charity supports impoverished children of Lesotho, South Africa.
Last year's Polo Classic drew A-listers like Madonna, Kate Hudson and LL Cool J.
Harry is third in line to the British throne.