Henderson's bold, graphic looks beat out Mila Hermanovski's 1960s-inspired black and white line and Emilio Sosa's color-inspired collection.
Sosa won the most challenges throughout the show's seventh season and finished runner-up. The Dominican-born designer slumped over and appeared to fight back tears when the results were announced.
Henderson wins $100,000 to continue work on his collection. The 38-year-old from Vancouver, Wash., says his first big splurge will be a vacation with his wife and two children. "Project Runway" airs on the Lifetime cable TV network.