In the national semifinals for the first time since 2004, Duke will play East Regional champion West Virginia on Saturday night. The Blue Devils have won 11 of their last 12 regional finals under Krzyzewski, but haven't won a national title since 2001.
Smith and Scheyer helped Duke offset a poor game from junior forward Kyle Singler, who was 0 for 10 from the field and made only five free throws. It was the first time in his college career he failed to hit a field goal.
LaceDarius Dunn had 22 points and Ekpe Udoh scored 18 for the Bears (28-8), whose program was in shambles when coach Scott Drew took over in the wake of murder and scandal less than seven years ago.
After tying the game for the 12th time on a free throw with 3:36 left, Smith missed his second attempt. But Lance Thomas grabbed the rebound and quickly passed the ball right back to Smith, who hit a 3-pointer from the right wing to put Duke up 64-61.
Scheyer extended the lead to six with his fifth 3-pointer.
Tweety Carter and Quincy Acy had 12 points each for Baylor.