Murray rushed 18 times for 80 yards and had five catches for 143 yards for Oklahoma (6-4, 4-2 Big 12), which put the game away in the first half by taking advantage of three lost fumbles by Texas A&M (5-5, 2-4), two of those on kick returns.
Jones completed 24 of 39 passes as Oklahoma rolled up season highs in offense (640 yards) and points. Chris Brown, Ryan Broyles and Adron Tennell scored two touchdowns each for Oklahoma, which has won seven straight against the Aggies. The Sooners have won 29 straight home games, the longest active streak in the FBS.
Oklahoma's defense limited Texas A&M to 226 yards of offense.