Patrol Sgt. Jon Baker says the driver went through a stop sign during the pursuit and collided with a pickup truck.
The Fresno Bee reports that five children were in the truck and four of them were ejected and died at the scene. It says the surviving child and two adults in that vehicle were taken to Community Regional Medical Center in Fresno.
The Bee also reports all three people in the car being followed by police were killed.
Baker says he couldn't confirm if the children who died were related.
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