De Matteo recently got engaged to country singer Shooter Jennings, with whom she has an 18-month-old daughter, Alabama.
De Matteo had a breakout role in "The Sopranos" as a mob girlfriend-turned-FBI informant. She later starred on the short-lived sitcom "Joey."
Last season, "Desperate Housewives" killed off original housewife Edie, played by Nicollette Sheridan.
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