The 25-year-old man was wounded Friday while driving a Bentley Continental on the 101 Freeway just south of downtown. His identity has not been released.
No arrests had been made and the motive for the attack was not immediately known. Police say they found shell casings along the freeway.
Two lanes on the busy freeway were reopened after the southbound side was shut down for nearly eight hours and snarled traffic for miles during the morning rush hours.
Police say the car had at least 10 bullet holes. Police say motorists stopped to help the driver after his vehicle hit a center median.
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