The actress' husband, Alex M. Young, filed for divorce in Los Angeles on Tuesday. His petition cites "irreconcilable differences" but offers no further details.
The pair married September 2007, and the documents say they separated Nov. 22. The couple have no children together.
Walsh, 41, is the star of the "Grey's Anatomy" spin-off "Private Practice" on ABC. Young is a top-ranking executive at 20th Century Fox.
A phone message left for Walsh's publicist Thursday was not immediately returned. The breakup was first reported on a Web site for "The Insider" television show.
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