It started some time before 6:30 a.m. at Partnership Way and Grand Circle Boulevard near Katy Freeway and Grand Parkway.
The fire quickly went to multiple alarms as Katy Fire Department crews on the scene were joined by crews from the Houston Fire Department.
Two buildings and six garages were destroyed by the flames that appeared to spread as firefighters continued to spray water.
Other crews were seen hosing down the roofs of nearby structures to keep them from catching fire.
It wasn't clear what caused the site to ignite.