It happened between Mason Road and the Grand Parkway around 7:50 p.m.
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Deputies said a silver Acura TL was driving eastbound in westbound lanes on the feeder road.
That's when the Acura hit a Kia Sportage SUV, causing an Acura TSX and a Toyota Yaris to crash into the silver Acura and the Kia.
The driver of the Acura TSX was rushed to the hospital. Officials say he is in stable condition.
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Deputies have not identified either person or said why the driver was going the wrong way on the feeder.
Officials say there were no other occupants in any of the vehicles besides the drivers.
A toxicology report is pending.