It happened on the North Freeway near the Research/Lake Woodlands exit around 12:45 a.m.
Officials said the wrong-way driver in a Ford Taurus was going southbound in the northbound lane when he hit a minivan.
Firefighters worked nearly 45 minutes to help get a man, a woman and the child out of the minivan.
The alleged wrong-way driver was taken to the hospital in stable condition.
Officials did not say if the wrong-way driver was intoxicated.