It happened around 12:30 a.m. at an apartment complex in the 10900 block of Gulf Freeway.
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The woman had parked her car at the complex when she saw a man trying to break in, according to Houston police.
The woman went inside and grabbed a gun before going outside to confront the burglar, police said. During the confrontation, the woman shot him in the leg.
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He was taken to the hospital and is expected to survive. He faces a burglary of a motor vehicle charge.
The woman isn't expected to face charges related to the shooting.