The fire broke out just before 7 p.m. Friday on York Street near Harrisburg.
Authorities told ABC13 Eyewitness News that a friend found the woman's apartment on fire after going to check on her.
Houston police said the female victim was found once the fire was put out. The fire was so intense, one firefighter had to be rescued after falling two floors.
We do not know the name of the victim or what started the fire. Investigators say they're still trying to locate the victim's husband for questioning.