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The Harris County Precinct 4 Constable's Office says crews responded to the fire in the 22500 block of Leafygate Drive in Spring.
Authorities say the elderly woman was transported to the hospital with severe burns.
A second woman was transported to the hospital out of precautionary measures, according to the Harris County Fire Marshal's Office.
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Crews are still working to figure out the cause of the fire.
Investigators did report that they encountered hoarder conditions inside the home.