The deadly crash happened around 12:15 a.m. Monday in the 8900 block of I-10 eastbound near the I-610 East Loop.
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Houston police said the Uber driver told officers a woman tried to get out of his vehicle while he was driving on the freeway. The driver said he locked the doors to prevent her from getting out while the car was moving. He then pulled over to the right shoulder, and the woman jumped out of the vehicle through the side window and ran across the entrance ramp, HPD said.
That's when the 28-year-old woman was fatally hit by a Ford F-250 pickup truck and several other vehicles, according to HPD.
The driver of the F-250 stopped and waited for police. Officers determined the driver was not impaired, police said.
The driver told police the other drivers who hit the woman initially stopped but left the scene before officers arrived.
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Police believe the woman got into some sort of disagreement with the Uber driver. Still, investigators were working to determine why the woman was trying to exit the vehicle.
Anyone with information about the other vehicles involved in this crash is urged to contact the HPD Hit and Run Unit at 713-247-4072 or speak anonymously to Crime Stoppers at 713-222-TIPS.