Officers responded to the parking lot of what used to be a tire shop at 3511 Telephone Road near the Gulf Freeway around 10:30 a.m. Tuesday.
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Investigators said the business burned down last year and is no longer operational.
At the scene, they found a woman fatally stabbed, according to HPD.
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Police said they believe the woman was killed within the last 24 hours.
Two witnesses were being questioned, including a friend who reportedly arrived at the scene before police and found the woman dead.
Investigators had not yet identified the victim.
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