Houston police identified 33-year-old Vincent Guerino Juliano as a person of interest in the woman's death. He is not charged at this time, but investigators would like to talk to him about what happened.
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HPD released a photo of the man on Tuesday in hopes that someone might know where he is.
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Officers responded to a report of a woman dead at the Red Carpet Inn located at 6868 Hornwood Drive in the Sharpstown area shortly before 9 p.m. Saturday.
At the scene, they found the victim dead inside a motel room with at least one gunshot wound.
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Further investigation revealed that Juliano rented the motel room with the victim.
Witnesses told police they heard screaming coming from the room and then a gunshot.
HPD said Juliano was seen leaving the location alone a short time later.
Anyone with information on Juliano's whereabouts is urged to contact the HPD Homicide Division at 713-308-3600 or Crime Stoppers at 713-222-TIPS.