This was Williams' 10th final at the All England Club, according to Wimbledon.
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She was attempting to win a record-tying 24 Grand Slam titles.
In an emotional post-match interview Williams said, "To all the moms out there. I was playing for you today, and I tried."
She went on to say she couldn't be disappointed because of how far she had gotten.
Kerber and Williams faced-off in the 2016 finals, where Williams was victorious.
In an interview, Kerber called Williams and inspiration and said she will have her next Grand Slam title soon.
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Williams was ranked 25th in this year's tournament after giving birth to a baby daughter in September. The All England Club amended the rules and seeded her, instead of following the ranking list that doesn't take into account players' taking a break for maternity leave. She was ranked No. 1 when she took her maternity leave and was ranked 183rd in the world after returning to the tour in March.
The Associated Press and ABC News contributed to this report.