The Harris County Sheriff's Office said its Vehicular Crimes Division looked into the crash on Westheimer, which is otherwise known as FM-1097, at Westheimer Place, which is just near George Bush Park.
HCSO tweeted that an adult driver struck a large trailer and died at the scene as a result. SkyEye flew over the scene and captured the aftermath of the crash, which involved a white SUV and a flatbed trailer carrying construction equipment.
Three westbound lanes of Westheimer Road were shut down, affecting traffic for a few hours.
"Please pray for the families affected," HCSO's Vehicular Crimes Division tweeted.
The crash scene is about four miles away from a previous wreck that Houston police were investigating Monday. An SUV driver was killed when he slammed into a tree on Briar Forest Drive in a separate crash.