It happened at about 11 p.m.
Authorities told ABC13 that Harris County Sheriff's Office deputies were chasing a suspect who ultimately caused multiple drivers to get caught up in the fray, as the crash happened at Bellaire Boulevard and Eldridge Parkway.
The damage was so bad, one person had to be rescued from a vehicle.
Two people were transported with injuries to Memorial Hermann Hospital Katy.
Deputies said the people injured were not involved in the chase.
ABC13 is working to learn more about the suspect deputies are looking for and why they were chasing that person.
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